CoE Objectives | Central Ayurveda Research Institute

Centre of excellence for research and clinical studies in Madhumeha (Diabetes mellitus)

Executive summary

Background

The Central Ayurveda Research Institute, Bengaluru is one of the peripheral Institutes of Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, Govt. of India. The Institute established in 1971 has been engaged in Clinical Research, Drug standardization and Survey of Medicinal Plants in addition to providing healthcare facilities to the needy public. In recognition of its contribution in patient care and research, the Ministry of Ayush, Govt. of India has awarded “Centre of excellence (CoE) for research and clinical services in Madhumeha (Diabetes mellitus)” in the year 2021 for a period of 6 years (3 years + 3 year extension).

Objectives

Development of comprehensive document on “Ayurvedic guideline for prevention and management of diabetes mellitus”
Validation of Ayurveda approaches for diabetes
Validation of Ayurveda dietetics and development of ready to cook/ready to eat food for diabetes
Prevention and management of diabetes mellitus with multi-specialty approach
Developing technical collaboration with reputed organisations
Capacity building for Ayurveda research in diabetes
To obtain certification from National Accreditation Board for Hospitals & Healthcare Providers (NABH)
To introduce e-healthcare initiatives (compliant with digital India) for prevention and management of Diabetes

Deliverables

Sl No.	Deliverables	Action Plan	1^st Year	2^nd Year	3^rd Year	4^th Year	5^th Year	Outcome indicators
01	Preparation of “Ayurvedic guideline for prevention and management of Madhumeha (Diabetes mellitus) ”	• Drafting • Validation/ finalisation	Draft will be ready in first 6 months		1st draft is ready for review	Draft under review	Guideline is ready, yet to be Published	• Publication of validated guideline
02	Validation of Ayurveda approaches for diabetes	A) Through planned clinical trials • Literature search and selection of intervention • Standardisation, preclinical safety toxicity, biological activity of selected formulations • Finalisation of protocol/documentation tools • Ethical committee approval / CTRI registration and initiation of trials B) Documentation of outcome of interventions used in routine OPD/IPD	Will be initiated in last 6 months		Done	Done	Validation of 200 patients Under progress	• Development of two formulations for diabetes • Documentation of at least 500 patients/ high-risk population Atleast two publications
03	Validation of Ayurveda dietetics and development of ready to cook/ready to eat food for Diabetes	• Literature search and selection of food recipes • Development of SOPs for preparation • Validation • Publication		Will be initiated in last 6 months	Initiated with clinical trial	Clinical Trial completed	Extended clinical trial on ready to cook recipe will be initiated	• Development of atleast two diet preparations for public use
04	Prevention and management of diabetes with multi-specialty approach	• Community IEC about diet, and lifestyle including yoga • Specialised training on Yoga / Ayurveda dietetics • Screening and management of high-risk population • Hospital based patient care • Referral of needy patients to Allopathy- integrated approach to follow • Documentation/ publication	Will be initiated during first 6 months		Complete	Complete	On going	• Number of beneficiaries • Outcome of stand alone/ integrated interventions in patients/ high-risk population Upgradation of infrastructure
05	Networking – operational and technical collaboration	• Networking with local governance • With Central/ State Govt. local hospitals for referrals and integrated care • Tie up for specialised investigations like gut microbiome analysis / genetic marker study etc. • For drug standardisation and preclinical studies, preparation of sample medicines. For development of diet		last 6 months	Complete	Complete	On going	• Effective collaborations happened • Successful completion of targets Management of referred cases
06	Capacity building for Ayurveda research in Diabetes	Training of human resources in research with special focus on diabetes		last 6 months	347 patients and 490 students were oriented.	397 patients and 547 students were oriented.		• Number of people trained • Number of people passing assessment parameters
07	NABH Accreditation	Upgradation of standards as per NABH guidelines to deliver quality healthcare		Will be initiated during first 6 months	Done	Done		• Obtaining NABH Accreditation certification
08	To introduce e-healthcare initiatives for prevention and management of Diabetes	Online appointment, telemedicine, e-records, digital IEC (literature, audio-visuals, SMS alerts etc.)				More than 5,00,000 population benefited	On going	• Successful initiation of e-health programmes

Budget

Total sanctioned for three years. :₹ 7,24,80,400/-
Budget released for the first year. : ₹ 2,88,00,000/-
Budget released for the Second year. : ₹ 2,76,46,200/-
Budget released for the Third year. : ₹ 1,58,34,200/-

Present status

Development of comprehensive document on Diabetes entitled “Reimagining Diabetes Care through the Lens of Ayurveda: An Integrated Framework for the Prevention and Management of madhumeha (Diabetes)” yet to publish.
Exclusive OPD for screening/management of diabetes started to function on 22.07.2021 and has catered to catered to 4,718 diabetic patients and 24,696 follow-up visits offering Ayurveda treatment totalling up to 29,414 visits.
8,937 patients have had free laboratory investigations under the scheme.
Free yoga classes were conducted at CARI Hospital and 1240 (for both OPD and IPD) patients have been benefitted.
A Diabetes predictive module has been developed using Machine learning and Artificial intelligence techniques in collaboration with experts from Centre for Incubation Innovation Research and Consultancy. Copy right form is received for the same and risk assessment portal is developed and made available in the institute website for the viewers to assess the risk of Diabetes.
Clinical trials for 2 selected anti-diabetic formulation completed.
Clinical trial to evaluate two ready to cook dietary supplements for its antidiabetic property in patients of type-2 diabetes mellitus is completed and taken up for extended clinical study.
Medical camps were conducted under CoE from time to time to screen patients for diabetes and diabetic-related issues, provide health-related education, doctor consultation, distribute medicines to treat diabetic and pre-diabetic problems and refer patients to the hospital for further follow-ups as needed, with the number of beneficiaries totalling to 2516.
10 Diabetes awareness talks for general public were conducted at various locations in Bengaluru with total beneficiaries being 748
20 special training programmes were conducted for patients of Diabetes at CARI Hospital focussing on understanding Diabetes, Diet in Diabetes and Lifestyle modifications in Diabetes with total beneficiaries –629
30 training programmes on Research methodology, Biostatistics, Chromatographic techniques and comprehensive management of Diabetes were conducted for Final year UG/First year PG students from different colleges of Karnataka with total number of trainees –1463.
26 Yoga training camps were held at various places around CARI Hospital with an intention to introduce Yoga and lifestyle changes in Diabetic and pre-diabetic populations.
e-healthcare initiatives are carried out through the website www.cari.gov.in has reached out to over 5,00,000 population.
Total population coverage under e-healthcare initiatives is 4,11,802.
6 Memorandums of Understanding have been signed under CoE with prestigious institutions like IISc Bengaluru for advanced research in Diabetes, Centre for Incubation Innovation Research and Consultancy for food technology, information technology & drug development, Nagpur Veterinary College for conduct of Pre-clinical safety/efficacy studies, Samatvam Science and Research for Human welfare Trust, Bengaluru for conduct of Clinical trials , CSIR-Central Food Technology Research Institute (CFTRI), Mysore for Diabetic diet research and Government Ayurveda Research Centre, Mysore for collaboration on academic programmes, research partnerships, and training.
10 IEC materials developed with special focus on diabetes including Yoga interventions.
NABH and NABL accreditation obtained to CARI hospital and CARI Clinical laboratory respectively.
16 articles published in peer reviewed journals, 2 accepted for publication and 4 Under review.
12 clinical studies, 1 pre clinical study and 1 case series have taken up after IEC clearance and CTRI registration and all the trials are completed.
Anti diabetic food preparation development underway in collaboration with reputed organisations viz. Centre for Incubation Innovation Research and Consultancy, Bengaluru and CSIR-Central Food Technology Research Institute (CFTRI), Mysore.